Repeated stress causes reversible impairments
of spatial memory performance
by
Luine V, Villegas M, Martinez C, McEwen BS.
Department of Psychology,
Hunter College, New York, NY 10021.
Brain Res. 1994 Mar 7;639(1):167-70.

ABSTRACT

Restraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.

Analgesic
Neuroplasticity
The Mss4 gene
Asthma prevention
Pharmacodynamics
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Tianeptine and Panic Disorder
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Neurobiology of mood, anxiety and emotion
Tianeptine (Stablon) versus fluoxetine (Prozac)
Synaptic plasticity in tianeptine-treated tree-shrews

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family