Influence of food on tianeptine and its main metabolite kinetics
by
Dresse A, Rosen JM, Brems H,
Masset H, Defrance R, Salvadori C.
Laboratoire de Pharmacologie,
Universite de Liege, Belgium.
J Clin Pharmacol. 1988 Dec;28(12):1115-9.

ABSTRACT

The influence of a test meal on the absorption and disposition of tianeptine (Stablon), a new antidepressant, was investigated in 12 healthy subjects in a two-way, randomized, open cross-over study. Single 12.5-mg oral doses of tianeptine were administered following a night of fasting or immediately after a standardized breakfast. When subjects received tianeptine under fasting conditions the lag time before absorption onset, and the time of the maximum plasma concentration were 0.55 +/- 0.26 hours and 1.29 +/- 0.29 hours, respectively. The maximum plasma concentration was 322 +/- 44 ng/mL, and the total area under the curve 994 +/- 248 ng/hr/mL. When tianeptine was given at the end of the meal, several significant changes were found for tianeptine kinetic parameters; the lag time increased by 0.3 hour and the maximum plasma concentration was lowered (decreased by 25%) and occurred later (tmax increased by 0.5 hour). However, no significant change was found in the area under the plasma concentration-time curve. The trend and extent of changes in the MC5 metabolite parameters were similar to those observed for the parent drug. Absorption of tianeptine is slightly delayed and slowed down without modification of its extent when tianeptine is given at the end of a meal. These slight changes are not clinically relevant for an antidepressant administered three times a day. Despite the changes observed, tianeptine may be given at meal times to improve compliance with treatment.

Cats
EEG study
Metabolism
Asthma prevention
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Memory consolidation
Tianeptine and Panic Disorder
Stress, memory and depression
Discriminative stimulus properties
Tianeptine prevents dendritic atrophy
Neurobiology of mood, anxiety and emotion
Glutamate receptor currents in the hippocampus
Major depression and impaired structural plasticity
Synaptic plasticity in tianeptine-treated tree-shrews
Stress-induced hippocampal atrophy and dysfunction
Tianeptine reduces proinflammatory cytokine production

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family