Benefit of tianeptine and morphine in a transgenic model
of familial amyotrophic lateral sclerosis
by
Chritin M, Savasta M, Besson G.
Service de Neurologie,
CHU de Grenoble,
Grenoble, France.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2006 Mar;7(1):32-7.

ABSTRACT

The familial form of amyotrophic lateral sclerosis (FALS) has been linked in some cases to dominant mutations in the gene encoding the Cu/Zn superoxide dismutase (SOD1) mutation. Transgenic mice bearing the G93A SOD1 mutation develop clinical symptoms and pathological features similar to those described in the human disease and represent a good model to explore the potential benefit of therapeutic agents. Using this animal model, we tested the efficacy of morphine and tianeptine treatments, separately and in association, on both disease progression and survival. Acute injection of either of them, administered daily and before the onset of the disease, significantly prolonged the survival of the transgenic mice.

Morphine
Neuroplasticity
Asthma prevention
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Apoptosis prevention
Tianeptine and Panic Disorder
The dopamine D2/D3 receptors
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Neurobiology of mood, anxiety and emotion

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family