Tianeptine as a slightly effective therapeutic option
for attention-deficit hyperactivity disorder
by
Niederhofer H.
Child and Adolescent Psychiatry,
Regional Hospital Bozen, Bolzano, Italy.
helmutniederhofer@yahoo.de
Neuropsychobiology. 2004;49(3):130-3.

ABSTRACT

OBJECTIVE: Because of the hypotonic side effect of clonidine, the use of tianeptine was studied as an alternative because of its longer excretion half-life, decreased sedative side effects and more selective binding profile. METHOD: We rated sixty-eight psychiatric outpatients diagnosed with attention-deficit hyperactivity disorder (ADHD) at baseline and while taking tianeptine to determine its efficacy as a treatment for ADHD and used comparisons of Conners' parent ratings within each subject to measure behavioral changes in the subjects. RESULTS: During tianeptine treatment, patients' mean scores improved significantly overall, and also for Conners' Hyperactivity, Inattention and Immaturity factors. CONCLUSIONS: This preliminary study indicates that tianeptine might be a slightly effective beneficial and useful treatment for ADHD, reducing hyperactive behaviors and enabling greater attentional ability with minimal side effects.

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