Behavioural effects of thieno and pyrazolo [2,1]
benzothiazepine derivatives in mice

by
Exposito-Orta MA, Albertos LM,
Darias V, Sanchez-Mateo CC.
Departamento de Farmacologia,
Facultad de Farmacia,
Universidad de La Laguna,
La Laguna, Tenerife, Spain.
Arzneimittelforschung. 2004;54(7):365-70.


ABSTRACT

Behavioural studies were conducted in mice with a number of hetero[2,1]benzothiazepine derivatives, analogues of tianeptine. Previously published studies in mice have shown that some of these compounds were effective in the tetrabenazine and Porsolt tests. In the present study, four of the 15 compounds under study potentiated the actions of 5-hydroxytryptophan (5-HTP, 50 mg/kg i.p.), but no significant antagonism of the apomorphine (16 mg/kg s.c.)-induced hypothermia and potentiation of the amphetamine actions was found. Moreover, some of them inhibited the stereotyped behaviour and/or climbing behaviour of low doses of apomorphine and compound 2 was effective in the plus-maze test. These compounds also produced a slight inhibition of exploratory behaviour in the holeboard test. On the other hand, no significant muscle relaxant and anticonvulsant activities were observed at any dose employed. Together, these data suggest that some of the compounds under study combine the antidepressant effects with additional neuroleptic or anxiolytic activities in mice.
Tianeptine drivers
Asthma prevention
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Ischaemic heart disease/depression
Neurobiology of mood, anxiety and emotion
Antidepressant comparisons: SSRIs v tianeptine
Tianeptine enantiomers and serotonin-induced behaviour


Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Good Drug Guide

The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family